Vestibular influence on the binocular control of vertical-torsional nystagmus after lesions in the interstitial nucleus of Cajal.

Article date: 2000/4/11

PubMed ID: 10757519

Journal name: Neuroreport (ISSN: 0959-4965)


The interstitial nucleus of Cajal (iC) is a center of the velocity-to-position integration for vertical and torsional eye movements. In addition, iC has projections to and from the vestibular nuclei. Therefore the vestibular influence on the binocular alignment of vertical-torsional nystagmus after unilateral reversible iC inactivations was investigated in the alert monkey using 3D binocular search-coil recordings. The nystagmus was compared with the eye muscle rotation axes, which were corrected for the tonic ocular torsion elicited by the iC inactivation. Rotation axes of nystagmus were different for both eyes and revealed a co-activation of eye muscles similar to the effects of electrical stimulation of the anterior canal nerve. This suggests that, in addition to the deficient neural integrator, a vestibular imbalance contributes to the vertical-torsional nystagmus after iC inactivations.

This document is available from: http://directlinks.cc/files/muscimol/10757519.pdf

Author List: Rambold H, Helmchen C, Büttner U

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Muscimol;

Mesh terms: Animals; Eye Movements/physiology; Functional Laterality; Macaca mulatta; Muscimol/adverse effects; Nerve Degeneration/chemically induced; Nystagmus, Pathologic/physiopathology; Oculomotor Muscles/physiopathology; Vestibular Nuclei/physiopathology; Vision, Binocular/physiology;

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