Electroencephalographic and behavioral effects of a GABA agonist (muscimol) on photosensitive epilepsy in the baboon, papio papio.

Article date: 1979/8/1

PubMed ID: 113208

Journal name: Epilepsia (ISSN: 0013-9580)


Muscimol, 0.25-1.0 mg/kg, i.v., was administered acutely to 4 adolescent baboons, Papio papio, that show photically induced epilepsy. On the EEG, slowing of background rhythms was associated with the appearance of spikes, polyspikes, and recurring symmetrical spike-wave complexes. These changes were maximal 0.5-2 hr after muscimol injection. Regular testing with intermittent light stimulation showed either no change from control responses or a more severe epileptiform EEG 0.1-3 hr after muscimol. Photically induced myoclonus was not modified by muscimol. Despite its GABA-abonist properties, muscimol is not an effective anticonvulsant.

This document is available from: http://directlinks.cc/files/muscimol/113208.pdf

Author List: Pedley T A, Horton R W, Meldrum B S

Publication Types: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

Substances mentioned in the article: Anticonvulsants; Oxazoles; Muscimol;

Mesh terms: Animals; Anticonvulsants/therapeutic use; Drug Evaluation, Preclinical; Electroencephalography; Haplorhini; Muscimol/therapeutic use; Oxazoles/therapeutic use; Papio; Photic Stimulation; Seizures/drug therapy;

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