113208

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113208 [2018/11/22 21:16] (current)
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 +====== Electroencephalographic and behavioral effects of a GABA agonist (muscimol) on photosensitive epilepsy in the baboon, papio papio.======
 +
 +** Article date:** 1979/8/1
 +~~META:date created = 1979-08-01~~
 +
 +** PubMed ID: 113208 **
 +
 +** Journal name: Epilepsia (ISSN: 0013-9580) **
 +
 +** ABSTRACT **
 +
 +Muscimol, 0.25-1.0 mg/kg, i.v., was administered acutely to 4 adolescent baboons, Papio papio, that show photically induced epilepsy. On the EEG, slowing of background rhythms was associated with the appearance of spikes, polyspikes, and recurring symmetrical spike-wave complexes. These changes were maximal 0.5-2 hr after muscimol injection. Regular testing with intermittent light stimulation showed either no change from control responses or a more severe epileptiform EEG 0.1-3 hr after muscimol. Photically induced myoclonus was not modified by muscimol. Despite its GABA-abonist properties, muscimol is not an effective anticonvulsant.
 +
 +===== ===== 
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 +{{gview 100%,​450px>​ http://​directlinks.cc/​files/​muscimol/​113208.pdf}}
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 +Author List: Pedley T A, Horton R W, Meldrum B S
 +
 +Publication Types: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
 +
 +Substances mentioned in the article: Anticonvulsants;​ Oxazoles; Muscimol; ​
 +
 +Mesh terms: Animals; Anticonvulsants/​therapeutic use; Drug Evaluation, Preclinical;​ Electroencephalography;​ Haplorhini; Muscimol/​therapeutic use; Oxazoles/​therapeutic use; Papio; Photic Stimulation;​ Seizures/​drug therapy; ​
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 +{{tag> Oxazoles Anticonvulsants Muscimol }}
 +
 +{{keywords>​ Oxazoles, Anticonvulsants,​ Muscimol}}
 +
  
113208.txt · Last modified: 2018/11/22 21:16 (external edit)