Article date: 1986/1/1
PubMed ID: 115048
Journal name: Psychopharmacology (ISSN: 0033-3158)
The effects of the GABA agonist muscimol and GABA antagonist picrotoxin were examined in 3-4-day-old deprived rat pups under conditions of low (absence of milk) and high (milk presence) activity baselines. A low dose of muscimol was observed to have activating effects under low baseline conditions, whereas higher doses of muscimol were observed to depress milk-induced activity and mouthing. Picrotoxin treatment was observed to increase activation of these neonates under both baseline conditions. Taken together, these results provide evidence for a functional GABAergic inhibition of behavior in the neonate.
Author List: Spear L P, Penson J, Linville D G
Publication Types: Journal Article; Research Support, U.S. Gov't, P.H.S.
Substances mentioned in the article: Picrotoxin; Muscimol; gamma-Aminobutyric Acid;
Mesh terms: Animals; Animals, Newborn/physiology; Behavior, Animal/drug effects; Muscimol/pharmacology; Picrotoxin/pharmacology; Rats; gamma-Aminobutyric Acid/physiology;
Citations: - 6405442