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115048 [2018/11/20 14:26] (current)
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 +====== GABA and behavioral inhibition in the neonatal rat pup.======
 +
 +** Article date:** 1986/1/1
 +~~META:date created = 1986-01-01~~
 +
 +** PubMed ID: 115048 **
 +
 +** Journal name: Psychopharmacology (ISSN: 0033-3158) **
 +
 +** ABSTRACT **
 +
 +The effects of the GABA agonist muscimol and GABA antagonist picrotoxin were examined in 3-4-day-old deprived rat pups under conditions of low (absence of milk) and high (milk presence) activity baselines. A low dose of muscimol was observed to have activating effects under low baseline conditions, whereas higher doses of muscimol were observed to depress milk-induced activity and mouthing. Picrotoxin treatment was observed to increase activation of these neonates under both baseline conditions. Taken together, these results provide evidence for a functional GABAergic inhibition of behavior in the neonate.
 +
 +===== ===== 
 +
 +Author List: Spear L P, Penson J, Linville D G
 +
 +Publication Types: Journal Article; Research Support, U.S. Gov't, P.H.S.
 +
 +Substances mentioned in the article: Picrotoxin; Muscimol; gamma-Aminobutyric Acid; 
 +
 +Mesh terms: Animals; Animals, Newborn/​physiology;​ Behavior, Animal/drug effects; Muscimol/​pharmacology;​ Picrotoxin/​pharmacology;​ Rats; gamma-Aminobutyric Acid/​physiology; ​
 +
 +Citations: ​  - //​[[6405442]]//​
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 +{{tag> gamma-Aminobutyric_Acid Picrotoxin Muscimol }}
 +
 +{{keywords>​ gamma-Aminobutyric Acid, Picrotoxin, Muscimol}}
 +
  
115048.txt · Last modified: 2018/11/20 14:26 (external edit)