Muscimol antagonism of morphine analgesia in rats.

Article date: 1979/9/1

PubMed ID: 1175692

Journal name: British journal of pharmacology (ISSN: 0007-1188)


1 Muscimol, a gamma-aminobutyric acid (GABA) receptor agonist, when injected intraventricularly antagonizes the antinociceptive effect of morphine given either subcutaneously or intraventricularly. The antagonistic effect of muscimol on morphine analgesia appears to be linearly related. 2 This finding provides support for the view that a GABA-ergic system is involved in morphine analgesia.

Author List: Mantegazza P, Tammiso R, Vicentini L, Zambotti F, Zonta N

Publication Types: Journal Article

Substances mentioned in the article: Oxazoles; Muscimol; Morphine;

Mesh terms: Animals; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine/antagonists & inhibitors; Muscimol/pharmacology; Oxazoles/pharmacology; Rats; Reaction Time/drug effects; Time Factors;

Citations: - Effect of muscimol on single unit activity of substantia nigra dopamine neurons.

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