119184

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119184 [2018/11/22 21:16] (current)
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 +====== L-histidine:​ effects on sensitivity of cat spinal neurones to amino acids.======
 +
 +** Article date:** 1979/10/1
 +~~META:date created = 1979-10-01~~
 +
 +** PubMed ID: 119184 **
 +
 +** Journal name: Neuroscience letters (ISSN: 0304-3940) **
 +
 +** ABSTRACT **
 +
 +L-Histidine enhanced the inhibitory actions of GABA, muscimol and beta-alanine rather than that of glycine on spinal neurones in pentobarbitone-anaesthetised cats. L-Histidine also enhanced the excitatory action of L-glutamate,​ D- and L-aspartate,​ L-homocysteate and especially that of quisqualate,​ whereas the actions of acetylcholine,​ kainate, N-methyl-D-aspartate and D-homocysteate were more commonly reduced. These actions of L-histidine are best ascribed to an effect on amino acid transport systems, probably of the low affinity type, which therefore appear to be partially responsible for the inactivation of exogenously administered amino acids.
 +
 +===== ===== 
 +
 +{{gview 100%,​450px>​ http://​directlinks.cc/​files/​muscimol/​119184.pdf}}
 +
 +Author List: Lodge D
 +
 +Publication Types: Journal Article
 +
 +Substances mentioned in the article: Amino Acids; Amino Acids, Diamino; Glutamates; beta-Alanine;​ Muscimol; Aspartic Acid; Histidine; gamma-Aminobutyric Acid; Kainic Acid; 
 +
 +Mesh terms: Amino Acids/​administration & dosage; Amino Acids, Diamino/​administration & dosage; Animals; Aspartic Acid/​administration & dosage; Cats; Drug Interactions;​ Glutamates/​administration & dosage; Histidine/​administration & dosage; Kainic Acid/​administration & dosage; Muscimol/​administration & dosage; Spinal Cord/drug effects; beta-Alanine/​administration & dosage; gamma-Aminobutyric Acid/​administration & dosage; ​
 +
 +{{tag> Amino_Acids Amino_Acids,​_Diamino Kainic_Acid Glutamates Histidine gamma-Aminobutyric_Acid Muscimol beta-Alanine Aspartic_Acid }}
 +
 +{{keywords>​ Amino Acids, Amino Acids, Diamino, Kainic Acid, Glutamates, Histidine, gamma-Aminobutyric Acid, Muscimol, beta-Alanine,​ Aspartic Acid}}
 +
  
119184.txt · Last modified: 2018/11/22 21:16 (external edit)