A GABAergic nigrotectal pathway for coordination of drinking behavior.

Article date: 2017/8/30

PubMed ID: 1278272

Journal name: Nature neuroscience (ISSN: 1546-1726)

DOI: 10.1038/nn.4285


The contribution of basal ganglia outputs to consummatory behavior remains poorly understood. We recorded from the substantia nigra pars reticulata (SNR), the major basal ganglia output nucleus, during self-initiated drinking in mice. The firing rates of many lateral SNR neurons were time-locked to individual licks. These neurons send GABAergic projections to the deep layers of the orofacial region of the lateral tectum (superior colliculus, SC). Many tectal neurons were also time-locked to licking, but their activity was usually in antiphase with that of SNR neurons, suggesting inhibitory nigrotectal projections. We used optogenetics to selectively activate the GABAergic nigrotectal afferents in the deep layers of the SC. Photo-stimulation of the nigrotectal projections transiently inhibited the activity of the lick-related tectal neurons, disrupted their licking-related oscillatory pattern and suppressed self-initiated drinking. These results demonstrate that GABAergic nigrotectal projections have a crucial role in coordinating drinking behavior.

Author List: Rossi Mark A, Li Haofang E, Lu Dongye, Kim Il Hwan, Bartholomew Ryan A, Gaidis Erin, Barter Joseph W, Kim Namsoo, Cai Min Tong, Soderling Scott H, Yin Henry H

Publication Types: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural

Article Date: 2016/04/04

Substances mentioned in the article: Muscimol;

Mesh terms: Action Potentials/physiology; Animals; Drinking Behavior/physiology; Female; GABAergic Neurons/physiology; Male; Mice; Mice, Transgenic; Microinjections; Muscimol/administration & dosage; Neural Inhibition/physiology; Neural Pathways/physiology; Pars Reticulata/physiology; Superior Colliculi/physiology;

Citations: - 1249606

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