Article date: 1992/11/1
PubMed ID: 1281891
Journal name: Journal of neuroscience research (ISSN: 0360-4012)
The effects of extracellularly applied recombinant human interleukin-2 (rhIL-2) on the gamma-aminobutyric acid (GABA)-induced Cl- current recorded from identified neurons (R9 and R12) of Aplysia kurodai were investigated with conventional voltage-clamp and pressure ejection techniques. Bath-applied rhIL-2 (10-40 U/ml) reduced the GABA-induced current in the neurons without affecting resting membrane conductance and the holding current. The suppressing effect of rhIL-2 on the current was completely reversible. Heat-inactivated rhIL-2 was without effect. These results suggest that the immunomodulator IL-2 can modulate the GABA-induced response in the nervous system.
Author List: Sawada M, Hara N, Ichinose M
Publication Types: Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: Chlorides; GABA Antagonists; Interleukin-2; Ion Channels; Recombinant Proteins; Picrotoxin; Muscimol; gamma-Aminobutyric Acid; Bicuculline;
Mesh terms: Animals; Aplysia/metabolism; Bicuculline/pharmacology; Chlorides/metabolism; GABA Antagonists; Ganglia/cytology; In Vitro Techniques; Interleukin-2/pharmacology; Ion Channels/drug effects; Membranes/drug effects; Muscimol/pharmacology; Neurons/metabolism; Picrotoxin/pharmacology; Recombinant Proteins/pharmacology; Seawater; gamma-Aminobutyric Acid/pharmacology;