Tunicamycin-induced inhibition of functional expression of glutamate receptors in Xenopus oocytes.

Article date: 1992/12/7

PubMed ID: 1283456

Journal name: Neuroscience letters (ISSN: 0304-3940)


The effects of tunicamycin, a specific inhibitor of N-linked glycosylation, on functional expression of glutamate receptor subtypes were investigated in RNA-injected oocytes. In the presence of tunicamycin the expression of ligand-operated receptors sensitive to kainate, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) and quisqualate were completely blocked. The inhibitory effect was reversible after removal of tunicamycin from the culture medium.

Author List: Musshoff U, Madeja M, Bloms P, Müsch-Nittel K, Speckmann E J

Publication Types: Journal Article

Substances mentioned in the article: Excitatory Amino Acid Antagonists; Ion Channels; Oligosaccharides; Receptors, Glutamate; Tunicamycin; Ibotenic Acid; RNA; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Quisqualic Acid; Kainic Acid;

Mesh terms: Animals; Electrophysiology; Excitatory Amino Acid Antagonists; Ibotenic Acid/analogs & derivatives; Ion Channels/drug effects; Kainic Acid/pharmacology; Oligosaccharides/metabolism; Oocytes/drug effects; Quisqualic Acid/pharmacology; RNA/biosynthesis; Receptors, Glutamate/biosynthesis; Tunicamycin/pharmacology; Xenopus laevis; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

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