Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse.

Article date: 1992/12/14

PubMed ID: 1284437

Journal name: Neuroscience letters (ISSN: 0304-3940)


Intrathecal injection of N-methyl-D-aspartate (NMDA) induces a short duration hyperalgesia in mice. An inhibitor of nitric oxide synthase (NOS), N omega-nitro-L-arginine methyl ester (L-NAME), administered either systemically or intrathecally, blocked the NMDA-induced hyperalgesia. This effect was partially reversed by the NOS substrate, L-arginine. Intrathecal hemoglobin mimicked the effects of L-NAME. Intrathecal injection of the NO-donating compounds, sodium nitroprusside (SNP) and hydroxylamine, resulted in a hyperalgesia that lasted 3 h and was reduced by coadministration of hemoglobin. Thus, nitric oxide production appears to mediate NMDA-induced hypersensitivity and may contribute to other forms of centrally induced hyperalgesia.

Author List: Kitto K F, Haley J E, Wilcox G L

Publication Types: Journal Article; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Hemoglobins; Hydroxylamines; Neurotoxins; Cycloleucine; 1-amino-1,3-dicarboxycyclopentane; Nitroprusside; Ibotenic Acid; Hydroxylamine; Nitric Oxide; N-Methylaspartate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Arginine; Nitric Oxide Synthase; Amino Acid Oxidoreductases; Kainic Acid; NG-Nitroarginine Methyl Ester;

Mesh terms: Amino Acid Oxidoreductases/antagonists & inhibitors; Animals; Arginine/administration & dosage; Cycloleucine/administration & dosage; Hemoglobins/administration & dosage; Hydroxylamine; Hydroxylamines/administration & dosage; Hyperalgesia/physiopathology; Ibotenic Acid/administration & dosage; Injections, Spinal; Kainic Acid/administration & dosage; Male; Mice; Mice, Inbred ICR; N-Methylaspartate/pharmacology; NG-Nitroarginine Methyl Ester; Neurotoxins/pharmacology; Nitric Oxide/metabolism; Nitric Oxide Synthase; Nitroprusside/administration & dosage; Spinal Cord/drug effects; Time Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

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