Effects of 5-HT1A receptor agonists on the circadian rhythm of wheel-running activity in hamsters.

Article date: 1992/4/7

PubMed ID: 1316283

Journal name: European journal of pharmacology (ISSN: 0014-2999)


The effects of 5-HT1A receptor agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), buspirone and ipsapirone on wheel-running activity in hamsters were investigated in comparison with those of GABAA receptor agonist muscimol and benzodiazepine triazolam. Intraperitoneal administration of 8-OH-DPAT, buspirone, ipsapirone, muscimol and triazolam at circadian time (CT) 8 (CT 12; onset of activity) induced a significant phase advance of wheel-running activity under constant light conditions. However, administration of these drugs at other CT points did not induce phase changes. The administration of trifluoromethylphenylpiperazine (TFMPP), a 5-HT1B receptor agonist, at CT8 produced a small phase advance. The phase advance induced by 8-OH-DPAT was blocked by pretreatment with (-)-pindolol, a 5-HT1A receptor antagonist. In addition, 8-OH-DPAT, buspirone and SM3997 accelerated the rate of re-entrainment to an 8-h phase advance in the light-dark cycle. These observations suggest that 5-HT1A receptors in the brain participate in the regulation of the circadian rhythm of wheel-running activity in hamsters.

This document is available from: http://directlinks.cc/files/muscimol/1316283.pdf

Author List: Tominaga K, Shibata S, Ueki S, Watanabe S

Publication Types: Journal Article

Substances mentioned in the article: Piperazines; Receptors, GABA-A; Receptors, Serotonin; Tetrahydronaphthalenes; 1-(3-trifluoromethylphenyl)piperazine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Pindolol; Melatonin; Buspirone;

Mesh terms: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone/pharmacology; Circadian Rhythm/drug effects; Cricetinae; Male; Melatonin/pharmacology; Mesocricetus; Motor Activity/drug effects; Pindolol/pharmacology; Piperazines/pharmacology; Receptors, GABA-A/analysis; Receptors, Serotonin/analysis; Tetrahydronaphthalenes/pharmacology;

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