1319502

Muscimol and N,N-dimethylmuscimol: from a GABA agonist to a glycine antagonist.

Article date: 1992/1/1

PubMed ID: 1319502

Journal name: Journal of neuroscience research (ISSN: 0360-4012)

ABSTRACT

By using molecular modeling methods, a molecular mechanism was identified which can explain how the incorporation of two methyl groups in place of two hydrogen atoms on the terminal nitrogen atom of muscimol can not only convert this potent agonist at GABAnergic receptors to an inactive molecule at these receptors, but also can convert this new derivative to an antagonist of glycine at glycinergic receptors. This insight into the molecular mechanism operative in the conversion of physiological function provides a basis for understanding how a single molecule may be able to act at both the GABA- and glycine-inhibitory receptors.

This document is available from: http://directlinks.cc/files/muscimol/1319502.pdf

Author List: Aprison M H, Lipkowitz K B

Publication Types: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Isoxazoles; Receptors, GABA-A; Receptors, Glycine; Receptors, Neurotransmitter; Muscimol; gamma-Aminobutyric Acid; N,N-dimethylmuscimol; N-methylmuscimol; 6-methyl-4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol; N,N-dimethylthiomuscimol; gaboxadol; Glycine;

Mesh terms: Chemical Phenomena; Chemistry, Physical; Computer Simulation; Glycine/antagonists & inhibitors; Isoxazoles/chemistry; Models, Molecular; Molecular Structure; Muscimol/analogs & derivatives; Receptors, GABA-A/drug effects; Receptors, Glycine; Receptors, Neurotransmitter/drug effects; Structure-Activity Relationship; gamma-Aminobutyric Acid/chemistry;

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