GABA receptor alterations after chronic lithium administration. Comparison with carbamazepine and sodium valproate.

Article date: 1992/7/1

PubMed ID: 1322549

Journal name: Progress in neuro-psychopharmacology & biological psychiatry (ISSN: 0278-5846)


1. Effects of lithium, carbamazepine, sodium valproate and baclofen on GABA receptors were examined in several regions of the rat brain. 2. [3H]Muscimol (MUS) and [3H] (-)baclofen (BAC) were used to label GABAA and GABAB receptors, respectively, in synaptic membranes from rat brain. 3. Single treatment with lithium chloride, carbamazepine or sodium valproate did not change [3H]MUS or [3H]BAC binding in the frontal cortex, hippocampus and thalamus. 4. Following chronic treatment with lithium, carbamazepine or sodium valproate, [3H]BAC binding was significantly increased in the hippocampus but not in the frontal cortex, thalamus or striatum. 5. [3H]Muscimol binding did not change in any region examined after chronic treatment with lithium, carbamazepine or sodium valproate. 6. Single and chronic administration of baclofen did not change [3H]MUS or [3H]BAC binding. 7. One common mechanism of action of mood stabilizers may be mediated by GABAB receptors in the hippocampus.

This document is available from: http://directlinks.cc/files/muscimol/1322549.pdf

Author List: Motohashi N

Publication Types: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Receptors, GABA-A; Muscimol; Carbamazepine; Valproic Acid; Lithium; Baclofen;

Mesh terms: Animals; Baclofen/pharmacology; Brain/drug effects; Carbamazepine/pharmacology; In Vitro Techniques; Lithium/pharmacology; Male; Muscimol/pharmacology; Rats; Rats, Inbred WKY; Receptors, GABA-A/drug effects; Valproic Acid/pharmacology;

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