[The neuropharmacological restoration of cognitive functions in cats after damage to the forebrain basal nuclei (Meynert's nucleus)].

Article date: 1992/5/1

PubMed ID: 1323181

Journal name: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova (ISSN: 0044-4677)


The cognitive functions were studied on experimental model of Alzheimer's disease (destruction of the basal nuclei of Meynert in cats) using the stimulation and inhibition of Ach, GABA, and DA brain systems. Ach system was found to be essential to form generalization function, DA system to improve simple learning, and GABA system to involve in formation of complex associations.

Author List: Mukhin E I, Nabieva T N, Mukhina Iu K

Publication Types: English Abstract; Journal Article

Substances mentioned in the article: Receptors, Cholinergic; Receptors, Dopamine; Receptors, GABA-A; Ibotenic Acid;

Mesh terms: Alzheimer Disease/chemically induced; Animals; Cats; Cognition/drug effects; Conditioning, Classical/drug effects; Disease Models, Animal; Female; Generalization (Psychology)/drug effects; Ibotenic Acid; Male; Receptors, Cholinergic/drug effects; Receptors, Dopamine/drug effects; Receptors, GABA-A/drug effects; Substantia Innominata/drug effects;

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