[Effects of GABA antagonist-induced seizures on 3H-muscimol and 3H-diazepam binding in the rat striatum].

Article date: 1992/1/1

PubMed ID: 1327278

Journal name: Biulleten' eksperimental'noi biologii i meditsiny (ISSN: 0365-9615)


The binding of 3H-muscimol and 3H-diazepam to rat striatum membranes after picrotoxin- and bicuculline-induced seizures was characterized. No alteration in the maximal binding capacity (Bmax) of 3H-muscimol was observed. However, bicuculline produced a 27% decrease in Kd. Both picrotoxin and bicuculline increased the binding capacity of 3H-diazepam. Bicuculline produced a 86% increase in Kd. These results suggest that the GABA antagonists-induced seizures may modulate 3H-muscimol and 3H-diazepam binding in rat striatum.

This document is available from: http://directlinks.cc/files/muscimol/1327278.pdf

Author List: Sofronov G A, Golovko A I

Publication Types: Comparative Study; English Abstract; Journal Article

Substances mentioned in the article: GABA Antagonists; Receptors, GABA-A; Tritium; Picrotoxin; Muscimol; Diazepam; Bicuculline;

Mesh terms: Animals; Bicuculline; Binding Sites; Corpus Striatum/metabolism; Diazepam/metabolism; GABA Antagonists; Male; Muscimol/metabolism; Picrotoxin; Rats; Receptors, GABA-A/metabolism; Seizures/chemically induced; Tritium;

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