GABAergic mediation of indirect transsynaptic control over basal and spatial memory testing-induced activation of septo-hippocampal cholinergic activity in mice.

Article date: 1992/9/28

PubMed ID: 1333220

Journal name: Behavioural brain research (ISSN: 0166-4328)


A neurochemical study of the transsynaptic interactions established between septal GABAergic interneurones and cholinergic septo-hippocampal neurones was conducted using mice. The effects of acute in vivo injections of either muscimol (20-500 ng/0.2 microliter), bicuculline (100 ng-1 micrograms/0.2 microliter) or saline vehicle (0.2 microliter) into the medial septum on septo-hippocampal cholinergic activity were evaluated using measures of hippocampal high affinity choline uptake at 30 min post-injection in two main groups of mice. The first (quiet control) remained in their home cages during the post-injection period whereas the second (active) were submitted, 10 min following injection to a 20-min period of spatial working memory testing in an 8-arm radial maze. Intraseptal injections of either muscimol or bicuculline produced significant (25-50%) inhibition of hippocampal cholinergic activity in quiet conditions (basal) as compared to intact or saline-injected mice. In the active groups, whereas memory testing induced significant cholinergic activation (+15-20%) in intact and saline injected mice at 30 s post-test no significant memory testing-induced activation was observed in either muscimol or bicuculline-injected mice at any dose. The role of septal GABAergic interneurones in the indirect transsynaptic control over the basal and activated states of septo-hippocampal cholinergic activity is discussed with respect to the concept that these complex neuronal interactions contribute to the physiological mechanisms involved in the modulation of working memory performance.

This document is available from: http://directlinks.cc/files/muscimol/1333220.pdf

Author List: Durkin T P

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Receptors, GABA-A; Muscimol; gamma-Aminobutyric Acid; Bicuculline;

Mesh terms: Animals; Bicuculline/pharmacology; Brain Mapping; Cholinergic Fibers/drug effects; Discrimination Learning/drug effects; Dose-Response Relationship, Drug; Exploratory Behavior/physiology; Hippocampus/drug effects; Injections; Male; Mental Recall/drug effects; Mice; Mice, Inbred BALB C; Muscimol/pharmacology; Neural Pathways/drug effects; Orientation/drug effects; Receptors, GABA-A/drug effects; Retention (Psychology)/drug effects; Septum Pellucidum/drug effects; Space Perception/drug effects; Substantia Innominata/drug effects; Synapses/drug effects; Synaptic Transmission/drug effects; gamma-Aminobutyric Acid/physiology;

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