Attenuation by the benzodiazepine receptor antagonist, ZK 93 426, of the deficit in spatial navigation induced by nucleus basalis lesions.

Article date: 1992/9/11

PubMed ID: 1333764

Journal name: Behavioral and neural biology (ISSN: 0163-1047)


The effects of the benzodiazepine receptor antagonist, beta-carboline ZK 93,426 treatment were studied both in NB-lesioned (ibotenic acid) and in unoperated Kuo-Wistar rats in a water maze task. The ZK 93,426 administered in the doses of 1 and 5 mg/kg, 30 min prior to the testing in a water maze apparatus, attenuated the NB lesion-induced spatial navigation deficit, although it had no effect on the performance of unoperated rats. The results suggest functional interactions between GABAergic system and ibotenic acid-induced lesion of the basal forebrain in rats.

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Author List: Mazurkiewicz M, Sirviö J, Riekkinen P

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Carbolines; GABA-A Receptor Antagonists; Receptors, GABA-A; ZK 93426; Choline O-Acetyltransferase;

Mesh terms: Analysis of Variance; Animals; Carbolines/pharmacology; Choline O-Acetyltransferase/analysis; GABA-A Receptor Antagonists; Male; Psychomotor Performance/physiology; Rats; Rats, Wistar; Receptors, GABA-A/physiology; Space Perception/drug effects; Substantia Innominata/physiology;

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