1335179

Naturally-occurring excitatory amino acids as neurotoxins and leads in drug design.

Article date: 1992/12/1

PubMed ID: 1335179

Journal name: Toxicology letters (ISSN: 0378-4274)

ABSTRACT

The central excitatory neurotransmitter (S)-glutamic acid (Glu) activates at least three types of receptors the NMDA, AMPA, and kainic acid (KAIN) receptors. These receptors mediate the neurotoxicity of a number of naturally-occurring Glu analogues. Thus, domoic acid, a KAIN receptor agonist, has probably been the cause of severe neurologic illness in people who consumed domoic acid poisoned food. beta-N-oxalylaminoalanine (beta-ODAP), an AMPA receptor agonist, has been associated with lathyrism, a spastic paraparesis caused by dietary intake of Lathyrus sativus. The neurotoxic Amanita muscaria constituent ibotenic acid, a nonselective NMDA receptor agonist, has been used as a lead structure for the development of the specific NMDA receptor agonist AMAA, AMPA, and a number of therapeutically interesting AMPA and KAIN receptor agonists.

This document is available from: http://directlinks.cc/files/muscimol/1335179.pdf

Author List: Krogsgaard-Larsen P, Hansen J J

Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Review

Substances mentioned in the article: Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Ibotenic Acid;

Mesh terms: Alzheimer Disease/etiology; Animals; Drug Design; Humans; Ibotenic Acid/pharmacology; Receptors, AMPA; Receptors, Glutamate/drug effects; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate/drug effects;

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