Changes in ligand binding to GABAA receptor sites in pacific salmon (Oncorhynchus) brain during spawning migration and "aging".

Article date: 1992/1/1

PubMed ID: 1336023

Journal name: Journal fur Hirnforschung (ISSN: 0021-8359)


When several years old, pacific salmon return to the site of birth, to spawn. At this time, a rapid aging process begins and the fish die within a few weeks after reproducing. Age-related changes of high and low affinity GABA binding sites were studied in salmon brains at three different phases of the spawning migration, i.e. shortly after returning to the natal stream, at the time of spawning, and thereafter. High affinity GABA binding slightly increased while the fish deteriorated. The low affinity component showed a remarkable decrease in density and a concomitant increase in affinity during this final episode of salmon life.

Author List: Erdö S L, Meyer D L, Malz C R, Hofmann M H, Ebbesson S O

Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Aminobutyrates; Analgesics; Isoxazoles; Ligands; Receptors, GABA-A; Muscimol; 2,4-diaminobutyric acid; gamma-Aminobutyric Acid; Baclofen; gaboxadol; Bicuculline;

Mesh terms: Aging/metabolism; Aminobutyrates/pharmacology; Analgesics/pharmacology; Animals; Baclofen/pharmacology; Bicuculline/pharmacology; Binding, Competitive; Brain/growth & development; Female; Isoxazoles/pharmacology; Kinetics; Ligands; Male; Muscimol/pharmacology; Receptors, GABA-A/metabolism; Salmon; Sexual Behavior, Animal; gamma-Aminobutyric Acid/metabolism;

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