Metabotropic glutamate receptor agonists potentiate a slow afterdepolarization in CNS neurons.

Article date: 1992/7/1

PubMed ID: 1358255

Journal name: Neuroreport (ISSN: 0959-4965)


We have previously reported that, in the rat dorsolateral septal nucleus (DLSN), metabotropic glutamate receptor (met-GluR) agonists evoked a slow depolarization accompanied by an increase in membrane conductance and burst firing. We have speculated that the burst firing elicited by met-GluR agonists may be due to activation or enhancement of a non-specific cation current, which exists in some DLSN neurons. Now we report that a slow afterdepolarization (sADP) mediated by a non-specific cation current was potentiated by both 1S,3R-ACPD and quisqualate. In addition, met-GluR agonists unmask a sADP in DLSN neurons which did not show a sADP under control conditions. Our data suggest that a non-specific cation current can be potentiated by activation of the met-GluR.

Author List: Zheng F, Gallagher J P

Publication Types: Journal Article; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Glutamates; Quinoxalines; Receptors, Glutamate; Cycloleucine; 1-amino-1,3-dicarboxycyclopentane; Ibotenic Acid; 6-Cyano-7-nitroquinoxaline-2,3-dione; Quisqualic Acid;

Mesh terms: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cycloleucine/analogs & derivatives; Evoked Potentials/drug effects; Glutamates/metabolism; Ibotenic Acid/pharmacology; In Vitro Techniques; Male; Membrane Potentials/drug effects; Neurons/drug effects; Prosencephalon/drug effects; Quinoxalines/pharmacology; Quisqualic Acid/pharmacology; Rats; Rats, Wistar; Receptors, Glutamate/drug effects;

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