Article date: 1992/12/1
PubMed ID: 1361876
Journal name: Brain research bulletin (ISSN: 0361-9230)
The probability of hippocampal long-term potentiation induction in the mossy fiber CA3 and commissural/associational CA3 responses and the cortical levels of choline acetyltransferase (ChAT) activity were compared in right nucleus basalis magnocellularis (NBM)-lesioned rats. A 50% reduction in the right cortical ChAT activity was demonstrated 4 weeks after an ibotenic acid lesion of the NBM. No significative differences were found in the probability of LTP induction of right hippocampal slices in sham-operated rats from 10 to 40 days after the injection into the right NBM. On the contrary, a progressive and significative increase in the probability of LTP induction was shown in right hippocampal slices of NBM-lesioned rats from 10 to 40 days after the injection of ibotenic acid into the right NBM. The results demonstrated the appearance of a paradoxical increase of hippocampal synaptic plasticity when the cortical cholinergic biochemical alterations are still present. This finding might be responsible for a behavioural recovery, in NBM-lesioned rats.
Author List: Frank C, Sagratella S, Niglio T, Caporali M G, Bronzetti E, Scotti de Carolis A
Publication Types: Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: Ibotenic Acid; N-Methylaspartate; 2-Amino-5-phosphonovalerate; Choline O-Acetyltransferase;
Mesh terms: 2-Amino-5-phosphonovalerate/pharmacology; Animals; Cerebral Cortex/drug effects; Choline O-Acetyltransferase/metabolism; Electric Stimulation; Hippocampus/drug effects; Ibotenic Acid; In Vitro Techniques; Male; N-Methylaspartate/antagonists & inhibitors; Nerve Fibers/drug effects; Olivary Nucleus/physiology; Pyramidal Tracts/physiology; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques;