N-methyl-D-aspartic acid (NMDA) and non-NMDA receptors regulating hippocampal norepinephrine release. I. Location on axon terminals and pharmacological characterization.

Article date: 1992/1/1

PubMed ID: 1370540

Journal name: The Journal of pharmacology and experimental therapeutics (ISSN: 0022-3565)


1) release-enhancing NMDA and non-NMDA receptors exist on noradrenergic axon terminals of rat hippocampus; 2) L-Asp appears to be a potent selective NMDA receptor agonist while L-Glu can activate also non-NMDA receptors; 3) the NE-releasing receptor activated by QA may represent a QA/AMPA receptor subtype.

Author List: Pittaluga A, Raiteri M

Publication Types: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Glutamates; Quinoxalines; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Ibotenic Acid; Aspartic Acid; Glutamic Acid; N-Methylaspartate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Quisqualic Acid; Magnesium; Kainic Acid; Norepinephrine;

Mesh terms: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid/pharmacology; Axons/drug effects; Glutamates/pharmacology; Glutamic Acid; Hippocampus/drug effects; Ibotenic Acid/analogs & derivatives; Kainic Acid/pharmacology; Magnesium/pharmacology; Male; N-Methylaspartate/pharmacology; Norepinephrine/secretion; Quinoxalines/pharmacology; Quisqualic Acid/antagonists & inhibitors; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface/drug effects; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate/drug effects; Receptors, Neurotransmitter/drug effects; Synaptosomes/drug effects; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

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