The metabotropic excitatory amino acid receptor agonist 1S,3R-ACPD selectively potentiates N-methyl-D-aspartate-induced brain injury.

Article date: 1992/5/14

PubMed ID: 1383003

Journal name: European journal of pharmacology (ISSN: 0014-2999)


The role of metabotropic type excitatory amino acid receptors in brain injury was assessed using the selective metabotropic receptor agonist, (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). Intrastriatal stereotaxic injection of 1S,3R-ACPD (250 nmol) in PND 7 rats produced little brain injury as assessed by hemispheric weight disparities. However, 1S,3R-ACPD markedly potentiated N-methyl-D-aspartate (NMDA)-, but not alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA)-, mediated brain injury. This effect was stereoselective since the inactive metabotropic agonist, 1R,3S-ACPD, did not potentiate NMDA toxicity.

Author List: McDonald J W, Schoepp D D

Publication Types: Journal Article

Substances mentioned in the article: Receptors, Amino Acid; Cycloleucine; 1-amino-1,3-dicarboxycyclopentane; Ibotenic Acid; N-Methylaspartate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

Mesh terms: Animals; Brain/drug effects; Cycloleucine/analogs & derivatives; Drug Synergism; Ibotenic Acid/analogs & derivatives; In Vitro Techniques; N-Methylaspartate/toxicity; Rats; Rats, Inbred Strains; Receptors, Amino Acid/drug effects; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

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