Effect of seizure activity and calpain inhibitor I on LTP in juvenile hippocampal slices.

Article date: 1992/8/1

PubMed ID: 1384274

Journal name: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience (ISSN: 0736-5748)


Kainic acid-induced seizure activity in adult rats produces an impairment of long-term potentiation induction in hippocampal slices. As the consequences of seizure activity are different in adult and juvenile rats, we tested the ability of hippocampal slices prepared from kainate-treated juvenile rats to exhibit long-term potentiation. Long-term potentiation was induced by theta-burst stimulation and was not significantly different in slices prepared from control or kainate-injected juvenile rats (16-18 postnatal days). Short-term potentiation, however, was reduced in the kainate-treated juveniles. Calpain inhibitor I has been shown to prevent long-term potentiation formation in adult hippocampal slices, and we evaluated its effect on long-term potentiation in hippocampal slices from juvenile rats. Calpain inhibitor I produced a significant reduction in the degree of long-term potentiation induced by theta-burst stimulation in hippocampal slices prepared from 14-20 postnatal day-old animals. The results are consistent with the notion that, although similar mechanisms participate in the formation of long-term potentiation in juvenile and adult animals, juvenile animals are much more resistant than adult animals to the consequences of seizure activity.

Author List: Fitzpatrick J S, Shahi K, Baudry M

Publication Types: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Glycoproteins; calpain inhibitors; Ibotenic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Phospholipases A; Kainic Acid;

Mesh terms: Animals; Cell Membrane/drug effects; Glycoproteins/pharmacology; Hippocampus/cytology; Ibotenic Acid/analogs & derivatives; In Vitro Techniques; Kainic Acid; Neuronal Plasticity/drug effects; Phospholipases A/pharmacology; Rats; Rats, Sprague-Dawley; Seizures/chemically induced; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

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