Basal forebrain cholinergic neurons in aged rat brain are more susceptible to ibotenate-induced degeneration than neurons in young adult brain.

Article date: 1992/9/4

PubMed ID: 1393599

Journal name: Brain research (ISSN: 0006-8993)


Choline acetyltransferase (ChAT) activity, acetylcholinesterase (AChE) activity, and [3H]nicotine binding site density were measured in neocortex from unoperated (control) and nucleus basalis (NB)-lesioned young (2-3 months old) and aged (23-24 months old) rats. In control animals, neither enzyme activities nor the density of nicotine binding sites were altered as a function of age. However, age-related differences were apparent 2 weeks following unilateral infusions of ibotenic acid into the right NB. NB lesion-induced decreases in enzyme activities were significantly greater in ipsilateral neocortices from aged rats; ChAT and AChE activities in young animals decreased by 59 and 53%, respectively, while both enzyme activities in aged rats decreased by 72%. NB lesions decreased significantly the density of nicotine binding sites in ipsilateral neocortices from both young and aged rats; binding decreased by 23-26% in young rats and by 31-34% in aged animals. Results indicate that the basal forebrain cholinergic system in the aged rat is more susceptible to ibotenate-induced degeneration than neurons in young animals.

Author List: Zawia N, Arendash G W, Wecker L

Publication Types: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Receptors, Nicotinic; Ibotenic Acid; Choline O-Acetyltransferase; Acetylcholinesterase;

Mesh terms: Acetylcholinesterase/metabolism; Aging/physiology; Animals; Cerebral Cortex/cytology; Choline O-Acetyltransferase/metabolism; Ibotenic Acid/toxicity; Male; Nerve Degeneration/drug effects; Neurons/drug effects; Parasympathetic Nervous System/cytology; Prosencephalon/cytology; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic/drug effects;

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