Inhibition of tetrahydroisoxazolo-pyridin-3-ol and muscimol and its mechanism on gastrointestinal transit in mice.

Article date: 1992/9/22

PubMed ID: 1425988

Journal name: European journal of pharmacology (ISSN: 0014-2999)


The effect of tetrahydroisoxazolo-pyridin-3-ol (THIP) and muscimol on gastrointestinal transit and a possible mechanism for this effect were studied using the charcoal meal test in mice. These agents inhibited transit dose relatedly. The inhibitory effect was completely reversed by yohimbine and phentolamine. A minor degree of antagonism by bicuculline was observed. There were an additive response in morphine-pretreated animals and partial antagonism in naloxone-pretreated animals. Propranolol failed to modify the inhibitory effect. The findings suggest a predominantly alpha 2-receptor-mediated inhibitory effect on gastrointestinal transit for THIP and muscimol which possibly also utilizes opioid pathways. However, it appears that beta-adrenergic and GABAergic systems might not contribute to this effect.

This document is available from: http://directlinks.cc/files/muscimol/1425988.pdf

Author List: Ramaswamy S, Srinivasan D, Bapna J S

Publication Types: Journal Article

Substances mentioned in the article: Isoxazoles; Muscimol; Yohimbine; Propranolol; gaboxadol; Bicuculline; Phentolamine;

Mesh terms: Animals; Bicuculline/pharmacology; Dose-Response Relationship, Drug; Drug Interactions; Gastrointestinal Transit/drug effects; Isoxazoles/antagonists & inhibitors; Male; Mice; Muscimol/antagonists & inhibitors; Phentolamine/pharmacology; Propranolol/pharmacology; Yohimbine/pharmacology;

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