Neurons in the hypothalamic paraventricular nucleus mediate the serotonergic stimulation of renin secretion.

Article date: 1992/10/9

PubMed ID: 1458311

Journal name: Brain research (ISSN: 0006-8993)


The aim of the present study was to resolve which hypothalamic nucleus is necessary for the serotonergic control of renin secretion. RU 24969 is considered a serotonin (5-HT1A/5-HT1B) agonist, while p-chloroamphetamine is a 5-HT releaser. Both drugs reliably elevate plasma levels of renin when injected peripherally. Previous studies suggest that serotonergic neurons, projecting to the hypothalamus, mediate the effect of p-chloroamphetamine on renin secretion. Discrete cell-selective lesions were made with ibotenic acid in three hypothalamic sites: the paraventricular, the dorsomedial or the ventromedial nuclei. Two weeks after surgery rats were injected with RU 24969 (5 mg/kg, i.p.) or p-chloroamphetamine (8 mg/kg, i.p.). The renin response to both RU 24969 and p-chloroamphetamine was significantly reduced in rats with histologically verified paraventricular lesions compared to vehicle treated controls. In contrast, the renin response to p-chloroamphetamine remained unchanged in rats with either dorsomedial or ventromedial hypothalamic lesions. Thus, these results are consistent with the hypothesis that 5-HT receptors located on cell bodies in the paraventricular nucleus mediate the renin response to a serotonin agonist and releaser. Furthermore, they confirm previous studies that suggest that 5-HT neurons regulate renin secretion through central receptors.

Author List: Rittenhouse P A, Li Q, Levy A D, Van de Kar L D

Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Indoles; Serotonin Antagonists; Serotonin Receptor Agonists; Ibotenic Acid; 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole; Serotonin; p-Chloroamphetamine; Renin;

Mesh terms: Analysis of Variance; Animals; Ibotenic Acid; Indoles/pharmacology; Male; Neurons/drug effects; Paraventricular Hypothalamic Nucleus/drug effects; Rats; Rats, Sprague-Dawley; Renin/secretion; Serotonin/physiology; Serotonin Antagonists/pharmacology; Serotonin Receptor Agonists/pharmacology; p-Chloroamphetamine/pharmacology;

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