1459733

Protection by muscimol against gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in spontaneously hypertensive rats.

Article date: 1992/12/2

PubMed ID: 1459733

Journal name: International journal of cancer (ISSN: 0020-7136)

ABSTRACT

The effects of prolonged administration of the gamma-aminobutyric acid receptor agonist muscimol on enhanced induction of gastric carcinogenesis by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in spontaneously hypertensive rats (SHR), and on the norepinephrine concentration in the gastric wall and the labeling index of gastric mucosa were investigated. SHR and normotensive Wistar Kyoto (WKY) rats as controls were given a solution of MNNG (25 micrograms/ml) for 25 weeks and then i.p. injections of 0.5 mg/kg body weight of muscimol every other day. In control WKY rats, gastric cancers were found in 1 (7%) of 14 rats examined at week 52. In SHR treated with NaCl solution only, the incidence of gastric cancers was significantly increased to 50% compared with that in control WKY rats. However, treatment of SHR with muscimol significantly increased its incidence to 12% compared with the value in SHR treated with NaCl solution only. The norepinephrine concentration in the gastric wall and the labeling index of the gastric mucosa were significantly greater in SHR than in WKY rats. Prolonged administration of muscimol to SHR significantly reduced the norepinephrine concentration in the antral portion of the gastric wall or the labeling index of the antral epithelial cells. These findings indicate that long-term treatment of SHR with muscimol attenuated the enhancement of gastric carcinogenesis in SHR.

This document is available from: http://directlinks.cc/files/muscimol/1459733.pdf

Author List: Tatsuta M, Iishi H, Baba M, Uehara H, Nakaizumi A, Taniguchi H

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Methylnitronitrosoguanidine; Muscimol; Norepinephrine;

Mesh terms: Analysis of Variance; Animals; Chi-Square Distribution; Gastric Fundus/innervation; Gastric Mucosa/drug effects; Male; Methylnitronitrosoguanidine; Muscimol/pharmacology; Norepinephrine/metabolism; Pyloric Antrum/innervation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Stomach Neoplasms/chemically induced;

1459733.txt ยท Last modified: 2018/11/22 21:16 (external edit)