Article date: 1992/3/1
PubMed ID: 1533937
Journal name: Pharmacology, biochemistry, and behavior (ISSN: 0091-3057)
Injections of the GABA agonist muscimol into the median raphe nucleus (MR) have been shown to result in an acceleration of dopamine metabolism within the nucleus accumbens. To examine whether serotonergic mechanisms play a role in this effect, muscimol or its vehicle was injected into the MR of either control subjects or of rats that had received prior injections of the serotonin-depleting agent p-chlorophenylalanine (PCPA). Although PCPA treatments produced massive depletions of forebrain serotonin, they failed to alter the effect of muscimol infusions on dopamine metabolism. This finding suggests that the effects of intra-MR injections of muscimol on accumbens dopamine turnover do not result entirely from an interaction between serotonergic and dopaminergic systems.
Author List: Wirtshafter D, Trifunovic R
Publication Types: Journal Article; Research Support, U.S. Gov't, P.H.S.
Substances mentioned in the article: 3,4-Dihydroxyphenylacetic Acid; Muscimol; Serotonin; Fenclonine; Dopamine; Homovanillic Acid;
Mesh terms: 3,4-Dihydroxyphenylacetic Acid/metabolism; Animals; Dopamine/metabolism; Fenclonine/pharmacology; Homovanillic Acid/metabolism; Male; Muscimol/pharmacology; Nucleus Accumbens/metabolism; Raphe Nuclei/drug effects; Rats; Rats, Inbred Strains; Serotonin/metabolism;