Article date: 1978/1/1
PubMed ID: 154957
Journal name: Comptes rendus des seances de la Societe de biologie et de ses filiales (ISSN: 0037-9026)
Muscimol, a rigid analogue of GABA has been injected in the CNS of urethane anesthetized, normotensive cats. Injected either intracisternally (1 or 2 microgram/kg, 0.05 ml) or directly by microinjection in a restricted ventrolateral region of the brain stem (0.5 or 1 microgram/kg, 0.5 microliter), muscimol induced hypotension and bradycardia. These central cardiovascular effects of muscimol were antagonized by bicuculline, a “specific” GABA antagonist agent. These data emphasize the involvement of gabergic mechanisms in the central cardiovascular control, at least in the ventrolateral part of the medulla oblongata.
Author List: Bousquet P, Feldman J, Bloch R, Schwartz J
Publication Types: English Abstract; Journal Article
Substances mentioned in the article: Oxazoles; Muscimol;
Mesh terms: Animals; Bradycardia/chemically induced; Brain Stem/drug effects; Cats; Female; Hypotension/chemically induced; Male; Muscimol/pharmacology; Oxazoles/pharmacology;