154957

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154957 [2018/11/20 14:26] (current)
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 +====== [Ventrobulbular hypotensive action of muscimol].======
 +
 +** Article date:** 1978/1/1
 +~~META:date created = 1978-01-01~~
 +
 +** PubMed ID: 154957 **
 +
 +** Journal name: Comptes rendus des seances de la Societe de biologie et de ses filiales (ISSN: 0037-9026) **
 +
 +** ABSTRACT **
 +
 +Muscimol, a rigid analogue of GABA has been injected in the CNS of urethane anesthetized,​ normotensive cats. Injected either intracisternally (1 or 2 microgram/​kg,​ 0.05 ml) or directly by microinjection in a restricted ventrolateral region of the brain stem (0.5 or 1 microgram/​kg,​ 0.5 microliter),​ muscimol induced hypotension and bradycardia. These central cardiovascular effects of muscimol were antagonized by bicuculline,​ a "​specific"​ GABA antagonist agent. These data emphasize the involvement of gabergic mechanisms in the central cardiovascular control, at least in the ventrolateral part of the medulla oblongata.
 +
 +===== ===== 
 +
 +Author List: Bousquet P, Feldman J, Bloch R, Schwartz J
 +
 +Publication Types: English Abstract; Journal Article
 +
 +Substances mentioned in the article: Oxazoles; Muscimol; ​
 +
 +Mesh terms: Animals; Bradycardia/​chemically induced; Brain Stem/drug effects; Cats; Female; Hypotension/​chemically induced; Male; Muscimol/​pharmacology;​ Oxazoles/​pharmacology; ​
 +
 +{{tag> Oxazoles Muscimol }}
 +
 +{{keywords>​ Oxazoles, Muscimol}}
 +
  
154957.txt · Last modified: 2018/11/20 14:26 (external edit)