Article date: 1992/5/1
PubMed ID: 1567030
Journal name: Anesthesia and analgesia (ISSN: 0003-2999)
We have recently reported a chronic allodynialike symptom in rats after ischemic spinal cord injury. This pain-related behavior is resistant to a number of pharmacologic treatments, including morphine, clonidine, carbamazepine, baclofen, and muscimol. In the present report, we present evidence indicating that systemic mexiletine, a local anesthetic and antiarrhythmic agent, effectively relieves the allodynia-like symptoms at doses of 15 and 30 mg/kg in these rats without inducing major side effects. It is suggested that systemically applied mexiletine may be useful in treating central pain in patients with spinal cord injury.
Author List: Xu X J, Hao J X, Seiger A, Arnér S, Lindblom U, Wiesenfeld-Hallin Z
Publication Types: Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: Mexiletine;
Mesh terms: Animals; Female; Injections, Intraperitoneal; Ischemia/complications; Mexiletine/therapeutic use; Motor Activity/drug effects; Pain/drug therapy; Pain Measurement; Rats; Rats, Inbred Strains; Spinal Cord Injuries/complications;