Systemic mexiletine relieves chronic allodynialike symptoms in rats with ischemic spinal cord injury.

Article date: 1992/5/1

PubMed ID: 1567030

Journal name: Anesthesia and analgesia (ISSN: 0003-2999)


We have recently reported a chronic allodynialike symptom in rats after ischemic spinal cord injury. This pain-related behavior is resistant to a number of pharmacologic treatments, including morphine, clonidine, carbamazepine, baclofen, and muscimol. In the present report, we present evidence indicating that systemic mexiletine, a local anesthetic and antiarrhythmic agent, effectively relieves the allodynia-like symptoms at doses of 15 and 30 mg/kg in these rats without inducing major side effects. It is suggested that systemically applied mexiletine may be useful in treating central pain in patients with spinal cord injury.

This document is available from: http://directlinks.cc/files/muscimol/1567030.pdf

Author List: Xu X J, Hao J X, Seiger A, Arnér S, Lindblom U, Wiesenfeld-Hallin Z

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Mexiletine;

Mesh terms: Animals; Female; Injections, Intraperitoneal; Ischemia/complications; Mexiletine/therapeutic use; Motor Activity/drug effects; Pain/drug therapy; Pain Measurement; Rats; Rats, Inbred Strains; Spinal Cord Injuries/complications;

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