Effect of the beta-adrenoceptor antagonist, propranolol, on feeding induced by noradrenaline and muscimol in rats kept at high and temperate-ambient temperatures.

Article date: 1992/1/28

PubMed ID: 1618267

Journal name: European journal of pharmacology (ISSN: 0014-2999)


Both the gamma-aminobutyric acid (GABA) receptor agonist, muscimol, and noradrenaline stimulated the feeding behavior of rats in the two environments. When noradrenaline or muscimol was administered, however, the food intake at 26 degrees C was greater than that at 33 degrees C. In addition, the stimulatory effect of noradrenaline on food intake was significantly depressed by propranolol pretreatment at both temperatures. The stimulatory effect of muscimol on food intake was significantly depressed by the propranolol pretreatment at 33 degrees C but not at 26 degrees C. Some eating-stimulatory subsystems associated with feeding behavior induced by noradrenaline or muscimol might have been depressed in the hot environment, thus the food intake increased by these drugs in rats acclimated to the hot environment was less than that in rats acclimated to the temperate environment.

This document is available from: http://directlinks.cc/files/muscimol/1618267.pdf

Author List: Kurose Y, Yano H, Miyazaki A

Publication Types: Comparative Study; Journal Article

Substances mentioned in the article: Muscimol; Propranolol; Norepinephrine;

Mesh terms: Animals; Feeding Behavior/drug effects; Male; Muscimol/pharmacology; Norepinephrine/pharmacology; Propranolol/pharmacology; Rats; Rats, Inbred Strains; Temperature;

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