Stimulation of prolactin and growth hormone secretion by muscimol, a gamma-aminobutyric acid agonist.

Article date: 1978/12/1

PubMed ID: 162520

Journal name: The Journal of clinical endocrinology and metabolism (ISSN: 0021-972X)


The alteration in circulating levels of PRL, GH, TSH, and cortisol was studied after the oral administration of muscimol (3-hydroxy-5-aminomethylisoxazole) to human subjects with Huntington's disease (n = 4) and chronic schizophrenia (n = 5). PRL levels rose significantly in a dose-dependent fashion within a 120-min time interval. GH rose significantly but modestly over the same time interval, whereas TSH and cortisol levels remained unchanged. Since muscimol is thought to be a potent and specific gamma-aminobutyric acid agonist, these data indicate that gamma-aminobutyric acid-mediated neural transmission may function to stimulate the release of plasma PRL and GH in human subjects.

This document is available from: http://directlinks.cc/files/muscimol/162520.pdf

Author List: Tamminga C A, Neophytides A, Chase T N, Frohman L A

Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Oxazoles; Muscimol; gamma-Aminobutyric Acid; Prolactin; Growth Hormone;

Mesh terms: Adult; Aged; Chronic Disease; Female; Growth Hormone/blood; Humans; Huntington Disease/blood; Kinetics; Male; Middle Aged; Muscimol/pharmacology; Oxazoles/pharmacology; Prolactin/blood; Schizophrenia/blood; gamma-Aminobutyric Acid/physiology;

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