162520

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162520 [2018/11/22 21:16] (current)
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 +====== Stimulation of prolactin and growth hormone secretion by muscimol, a gamma-aminobutyric acid agonist.======
 +
 +** Article date:** 1978/12/1
 +~~META:date created = 1978-12-01~~
 +
 +** PubMed ID: 162520 **
 +
 +** Journal name: The Journal of clinical endocrinology and metabolism (ISSN: 0021-972X) **
 +
 +** ABSTRACT **
 +
 +The alteration in circulating levels of PRL, GH, TSH, and cortisol was studied after the oral administration of muscimol (3-hydroxy-5-aminomethylisoxazole) to human subjects with Huntington'​s disease (n = 4) and chronic schizophrenia (n = 5). PRL levels rose significantly in a dose-dependent fashion within a 120-min time interval. GH rose significantly but modestly over the same time interval, whereas TSH and cortisol levels remained unchanged. Since muscimol is thought to be a potent and specific gamma-aminobutyric acid agonist, these data indicate that gamma-aminobutyric acid-mediated neural transmission may function to stimulate the release of plasma PRL and GH in human subjects.
 +
 +===== ===== 
 +
 +{{gview 100%,​450px>​ http://​directlinks.cc/​files/​muscimol/​162520.pdf}}
 +
 +Author List: Tamminga C A, Neophytides A, Chase T N, Frohman L A
 +
 +Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
 +
 +Substances mentioned in the article: Oxazoles; Muscimol; gamma-Aminobutyric Acid; Prolactin; Growth Hormone; ​
 +
 +Mesh terms: Adult; Aged; Chronic Disease; Female; Growth Hormone/​blood;​ Humans; Huntington Disease/​blood;​ Kinetics; Male; Middle Aged; Muscimol/​pharmacology;​ Oxazoles/​pharmacology;​ Prolactin/​blood;​ Schizophrenia/​blood;​ gamma-Aminobutyric Acid/​physiology; ​
 +
 +{{tag> Growth_Hormone Prolactin gamma-Aminobutyric_Acid Muscimol Oxazoles }}
 +
 +{{keywords>​ Growth Hormone, Prolactin, gamma-Aminobutyric Acid, Muscimol, Oxazoles}}
 +
  
162520.txt ยท Last modified: 2018/11/22 21:16 (external edit)