Activation of basal forebrain cholinergic neurons differentially regulates brain-derived neurotrophic factor mRNA expression in different projection areas.

Article date: 1992/3/2

PubMed ID: 1641192

Journal name: Neuroscience letters (ISSN: 0304-3940)


Afferent cholinergic pathways from the basal forebrain were activated by injections of the glutamate analog quisqualate either into the nucleus basalis or into the medial septal nucleus. Nucleus basalis injections had no effect on the expression of brain-derived neurotrophic factor (BDNF) mRNA in its neocortical projection areas as measured by in situ hybridization. In contrast, 7 h after an injection into the septum the level of BDNF mRNA increased 3- to 5-fold in the dentate gyrus, throughout CA1 to CA3 in the hippocampus and in the piriform cortex.

This document is available from: http://directlinks.cc/files/muscimol/1641192.pdf

Author List: Boatell L L, Lindefors N, Ballarin M, Ernfors P, Mahy N, Persson H

Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Brain-Derived Neurotrophic Factor; Nerve Tissue Proteins; RNA, Messenger; Muscimol; Quisqualic Acid;

Mesh terms: Afferent Pathways/cytology; Animals; Basal Ganglia/cytology; Brain-Derived Neurotrophic Factor; Hippocampus/cytology; Male; Muscimol/pharmacology; Nerve Tissue Proteins/biosynthesis; Neurons/physiology; Nucleic Acid Hybridization; Parasympathetic Nervous System/cytology; Prosencephalon/cytology; Quisqualic Acid/pharmacology; RNA, Messenger/biosynthesis; Rats; Rats, Inbred Strains; Stereotaxic Techniques;

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