Article date: 1991/3/29
PubMed ID: 1645612
Journal name: Brain research (ISSN: 0006-8993)
Bilateral injection of 2-amino-7-phosphonoheptanoate (2-APH), a selective N-methyl-D-aspartate (NMDA) receptor antagonist, into substantia nigra pars reticulata (SNpr) significantly and dose-dependently suppressed tonic pentylenetetrazol (PTZ) seizures (100 mg/kg, i.p.). The results confirm the anticonvulsant effectiveness of 2-APH and the capacity of SNpr to modulate PTZ seizure activity. The anti-PTZ effect of 2-APH was significantly attenuated by muscimol, co-infused into SNpr. This result supports the hypothesis, drawn from earlier studies, that intranigral muscimol can interfere with the anti-PTZ actions of other intranigral treatments.
Author List: Xie X H, Tietz E I, Rosenberg H C
Publication Types: Journal Article; Research Support, U.S. Gov't, P.H.S.
Substances mentioned in the article: Amino Acids; Anticonvulsants; Drug Combinations; Pharmaceutical Vehicles; Receptors, GABA-A; Muscimol; 2-Amino-5-phosphonovalerate; 2-amino-7-phosphonoheptanoic acid; Pentylenetetrazole;
Mesh terms: 2-Amino-5-phosphonovalerate/analogs & derivatives; Amino Acids/administration & dosage; Animals; Anticonvulsants/administration & dosage; Drug Combinations; Male; Muscimol/administration & dosage; Pentylenetetrazole; Pharmaceutical Vehicles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures/chemically induced; Substantia Nigra/metabolism;