Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys.

Article date: 1991/3/1

PubMed ID: 1646968

Journal name: Neurobiology of aging (ISSN: 0197-4580)


In this quantitative neurochemical study we investigated age-related changes in the GABAergic, glutamatergic, and cholinergic neurotransmitter systems in rats and rhesus monkeys. Sixteen young (5 months) and 20 aged (24 months) rats and seven “young” (4-9 years), six “adult” (20-25 years), and five “aged” (29-34 years) monkeys were studied. NMDA-displaceable 1-[3H]glutamate binding was significantly decreased in many neocortical and subcortical regions examined in aged rats and monkeys. The level of choline acetyltransferase (ChAT) activity and [3H]muscimol binding were unchanged in aged animals.

This document is available from: http://directlinks.cc/files/muscimol/1646968.pdf

Author List: Wenk G L, Walker L C, Price D L, Cork L C

Publication Types: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Muscimol; Choline O-Acetyltransferase;

Mesh terms: Aging/metabolism; Animals; Binding, Competitive/drug effects; Brain/anatomy & histology; Brain Chemistry/physiology; Choline O-Acetyltransferase/metabolism; Macaca mulatta; Muscimol/metabolism; Rats; Rats, Inbred F344; Receptors, GABA-A/physiology; Receptors, N-Methyl-D-Aspartate/physiology;

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