Phosphatidylserine increases the affinity of the AMPA/quisqualate receptor in rat brain membranes.

Article date: 1991/3/1

PubMed ID: 1647760

Journal name: Behavioral and neural biology (ISSN: 0163-1047)


We investigated the effects of phospholipids and cholesterol on the binding of [3H]-AMPA to rat telencephalic membranes. Phosphatidylcholine, phosphatidylethanolamine, sphingomyelin, and cholesterol were without effect at concentrations up to 1.5 mg/mg protein. Only phosphatidylserine increased [3H]-AMPA binding in a dose-dependent manner. This effect was due to an increase in the affinity of the low affinity component of [3H]-AMPA binding. These results indicate that the distribution of phosphatidylserine in membranes modulates the properties of the AMPA/quisqualate receptor.

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Author List: Baudry M, Massicotte G, Hauge S

Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Substances mentioned in the article: Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylserines; Receptors, AMPA; Receptors, Neurotransmitter; Sphingomyelins; Ibotenic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cholesterol;

Mesh terms: Animals; Brain/drug effects; Cholesterol/pharmacology; Ibotenic Acid/analogs & derivatives; Phosphatidylcholines/pharmacology; Phosphatidylethanolamines/pharmacology; Phosphatidylserines/pharmacology; Rats; Receptors, AMPA; Receptors, Neurotransmitter/drug effects; Sphingomyelins/pharmacology; Synaptic Membranes/drug effects; Synaptic Transmission/drug effects; Telencephalon/drug effects; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

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