Article date: 1991/4/1
PubMed ID: 1648694
Journal name: Neuroscience letters (ISSN: 0304-3940)
The present study deals with the role of the gamma-aminobutyric acid-A (GABAA) receptor in motor activity in the rostral part of the ventral pallidum/substantia innominata complex. Both the specific GABAA antagonist bicuculline (25-100 ng/0.5 microliter) and the GABAA agonist muscimol (25 ng/0.5 microliter) enhanced motor activity. It was moreover found that bicuculline (50-100 ng) dose-dependently attenuated the activity induced by muscimol (25 ng). Conversely, muscimol (25 ng) attenuated the bicuculline (25-50 ng) induced activity. These data thus show that both stimulation and blockade of GABAA receptors within the area under study enhance motor activity.
Author List: van den Bos R, Cools A R
Publication Types: Journal Article
Substances mentioned in the article: Receptors, GABA-A; Muscimol; Bicuculline;
Mesh terms: Animals; Bicuculline/pharmacology; Dose-Response Relationship, Drug; Globus Pallidus/anatomy & histology; Male; Motor Activity/drug effects; Muscimol/pharmacology; Rats; Rats, Inbred Strains; Receptors, GABA-A/drug effects;