Article date: 1991/3/1
PubMed ID: 1650116
Journal name: Acta physiologica Scandinavica (ISSN: 0001-6772)
The effects of handling habituation and swimming stress on ethanol-induced motor impairment and the GABAA receptor function were studied in adult male Wistar rats. Daily handling for 3 to 5 weeks had no significant effect on ethanol-induced motor impairment in the tilting plane test or on the activity of the rats in the elevated plus-maze test of anxiety. Plasma corticosterone concentrations were greatly elevated by the tilting plane test procedure, irrespective of handling habituation. Acute, 10-min swimming stress at +25 degrees C produced an elevated plasma corticosterone concentration comparable to that produced by the tilting plane test, again irrespective of handling habituation. In cerebrocortical homogenates, short-term swimming stress had no statistically significant effect on the muscimol stimulation of the GABAA receptor-mediated 36Cl- flux in handled and non-handled animals. Thus, handling habituation and stress had only minor effects on the activity of the central GABAergic systems in acute tests at behavioural and biochemical levels.
Author List: Tuominen K, Korpi E R
Publication Types: Journal Article
Substances mentioned in the article: Receptors, GABA-A; Ethanol; Corticosterone;
Mesh terms: Animals; Corticosterone/blood; Ethanol/pharmacology; Habituation, Psychophysiologic; Handling (Psychology); Male; Motor Activity/drug effects; Rats; Rats, Inbred Strains; Receptors, GABA-A/metabolism; Stress, Physiological/metabolism; Swimming;