Oxotremorine attenuates retrograde amnesia induced by post-training administration of the GABAergic agonists muscimol and baclofen.

Article date: 1991/7/1

PubMed ID: 1651077

Journal name: Behavioral and neural biology (ISSN: 0163-1047)


These experiments examined the involvement of cholinergic influences in the effects of GABAergic drugs on 24-h retention of an inhibitory avoidance response by mice. A first set of experiments confirmed previous findings indicating that post-training injections (ip) of the GABAergic agonists muscimol (1.0 and 2.0 mg/kg) and baclofen (10.0 and 20.0 mg/kg) impaired retention, as well as previous findings indicating that injections of the cholinergic agonist oxotremorine (5.0 and 10.0 micrograms/kg) enhanced retention. The findings of a second set of experiments indicated that the memory-impairing effects of muscimol and baclofen were attenuated by concurrent injections of a low, and otherwise ineffective, dose of oxotremorine (2.5 micrograms/kg). These findings are interpreted as suggesting that GABAergic drugs affect memory storage through influences on cholinergic systems.

This document is available from: http://directlinks.cc/files/muscimol/1651077.pdf

Author List: Castellano C, McGaugh J L

Publication Types: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Receptors, Cholinergic; Receptors, GABA-A; Muscimol; Oxotremorine; Baclofen;

Mesh terms: Animals; Avoidance Learning/drug effects; Baclofen/antagonists & inhibitors; Brain/drug effects; Conditioning, Classical/drug effects; Dose-Response Relationship, Drug; Male; Mental Recall/drug effects; Mice; Mice, Inbred Strains; Muscimol/antagonists & inhibitors; Oxotremorine/pharmacology; Reaction Time/drug effects; Receptors, Cholinergic/drug effects; Receptors, GABA-A/drug effects; Retention (Psychology)/drug effects;

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