Article date: 1991/4/1
PubMed ID: 1651515
Journal name: Pharmacology, biochemistry, and behavior (ISSN: 0091-3057)
The present study investigated the effects of serotonergic depletion upon the performance of rats with lesions of the nucleus basalis magnocellularis (NBM) in a nonspatial memory task. NBM lesions were made by injections of ibotenic acid. Serotonin was depleted by systemic injections of p-chloroamphetamine (PCA). After four weeks of testing, the choice accuracy of PCA rats was not different from that of control rats (CON), while the choice accuracy of NBM rats and rats with combined treatment (NBM + PCA) was significantly lower than CON rats, but not different from each other. After prolonged testing, performance improved in NBM rats, but not in NBM + PCA rats indicating that simultaneous loss of both cholinergic and serotonergic neurotransmission produced a significantly longer lasting behavioral deficit than the loss of cholinergic neurotransmission alone.
Author List: Markowska A L, Wenk G L
Publication Types: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
Substances mentioned in the article: Ibotenic Acid; Serotonin; Scopolamine Hydrobromide; p-Chloroamphetamine; Choline O-Acetyltransferase; Methysergide;
Mesh terms: Animals; Behavior, Animal/drug effects; Choline O-Acetyltransferase/metabolism; Ibotenic Acid; Male; Memory/drug effects; Methysergide/pharmacology; Olivary Nucleus/drug effects; Rats; Scopolamine Hydrobromide/pharmacology; Serotonin/physiology; Synaptic Transmission/drug effects; p-Chloroamphetamine/pharmacology;