Microinjections of muscimol and bicuculline into the pontine reticular formation modify the sleep-waking cycle in the rat.

Article date: 1991/8/5

PubMed ID: 1656343

Journal name: Neuroscience letters (ISSN: 0304-3940)


The role of gamma-aminobutyric acid (GABA) in the sleep-waking cycle was evaluated by means of microinjections of muscimol and bicuculline into the rat pontine reticular formation (PRF). Muscimol (20 ng) produced a marked increase in wakefulness (70%), a decrease in slow-wave sleep (SWS) (35%) and a remarkable delay in the onset of both SWS and paradoxical sleep, without modifying the percentage of the latter. Bicuculline (4 ng) shortened SWS latency by about 70%. These results suggest that GABAergic transmission in the PRF is involved in the regulation of sleep-waking cycle in the rat.

This document is available from: http://directlinks.cc/files/muscimol/1656343.pdf

Author List: Camacho-Arroyo I, Alvarado R, Manjarrez J, Tapia R

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Receptors, GABA-A; Muscimol; Bicuculline;

Mesh terms: Animals; Bicuculline/administration & dosage; Male; Microinjections; Muscimol/administration & dosage; Pons/drug effects; Rats; Rats, Inbred Strains; Receptors, GABA-A/physiology; Reticular Formation/drug effects; Sleep/drug effects; Synaptic Transmission; Wakefulness/drug effects;

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