Article date: 1991/8/19
PubMed ID: 1661214
Journal name: Brain research. Developmental brain research (ISSN: 0165-3806)
In the present study, we compared the effect of phospholipase A2 (PLA2) treatment of synaptic membranes from adult and neonatal rats on the characteristics of [3H]AMPA binding sites. Whereas PLA2 treatment of membranes from adult rats produces an increased affinity for [3H]AMPA binding, the same treatment in neonatal rats results in a decrease in the maximal number of binding sites. Since activation of PLA2 has been proposed to play a critical role in the formation of long-term potentiation (LTP), possibly mediated through a modification of the AMPA receptors, the results strengthen the hypothesis that PLA2-induced modification of [3H]AMPA binding sites is an important component of synaptic plasticity.
Author List: Baudry M, Massicotte G, Hauge S
Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Substances mentioned in the article: Receptors, AMPA; Receptors, Neurotransmitter; Ibotenic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Phospholipases A; Phospholipases A2;
Mesh terms: Aging/metabolism; Animals; Animals, Newborn/metabolism; Ibotenic Acid/analogs & derivatives; Kinetics; Male; Phospholipases A/pharmacology; Phospholipases A2; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Neurotransmitter/drug effects; Synaptic Membranes/drug effects; Telencephalon/growth & development; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;