Activation of AMPA/kainic acid glutamate receptors in the zona incerta stimulates locomotor activity.

Article date: 1991/11/8

PubMed ID: 1663813

Journal name: Brain research (ISSN: 0006-8993)


Direct injections of DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), an AMPA/quisqualic acid receptor agonist, into the medial or posterior zona incerta (ZI) produced a marked stimulation of locomotor activity accompanied by a postural change. Similar responses were obtained by injection of kainic acid (KA) into the same areas. The behavioral effects of AMPA and KA were antagonized by coinjection of 6,7-dinitroquinoxaline-2,3-dione (DNQX), and non-N-methyl-D-aspartate (NMDA) glutamate receptor antagonist. In contrast, injections of NMDA or ibotenic acid failed to significantly stimulate locomotor activity. These results suggest that the AMPA/kainate glutamate receptor subtypes in the zona incerta may have a functional role in regulating locomotor activity.

Author List: Supko D E, Uretsky N J, Wallace L J

Publication Types: Journal Article

Substances mentioned in the article: Quinoxalines; Receptors, AMPA; Receptors, GABA-A; Receptors, Kainic Acid; Receptors, Neurotransmitter; Ibotenic Acid; FG 9041; N-Methylaspartate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Kainic Acid;

Mesh terms: Animals; Diencephalon/physiology; Ibotenic Acid/analogs & derivatives; Injections; Kainic Acid/pharmacology; Male; Motor Activity/drug effects; N-Methylaspartate/pharmacology; Quinoxalines/administration & dosage; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, GABA-A/drug effects; Receptors, Kainic Acid; Receptors, Neurotransmitter/drug effects; Substantia Nigra; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

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