Article date: 1991/9/1
PubMed ID: 1664108
Journal name: Pharmacology, biochemistry, and behavior (ISSN: 0091-3057)
To determine the influence of intrinsic neurons of the dorsal hippocampus on dopamine (DA) turnover in other limbic areas, DA and its metabolites were assayed in several brain areas 14 and 28 days after bilateral ibotenic acid (IA) lesions of the dorsal hippocampus in the rat. The locomotor response to d-amphetamine was also assessed. Spontaneous locomotion was increased 14 but not 28 days postoperatively. There was no change in d-amphetamine-induced locomotion at any time. Presynaptic indices of DA turnover in the medial prefrontal cortex, anteromedial striatum and nucleus accumbens were not affected by the lesion. Unlike lesions of the medial prefrontal cortex, deefferentation of the dorsal hippocampus does not increase DA turnover in the basal ganglia.
Author List: Lipska B K, Jaskiw G E, Karoum F, Phillips I, Kleinman J E, Weinberger D R
Publication Types: Journal Article
Substances mentioned in the article: 3,4-Dihydroxyphenylacetic Acid; Ibotenic Acid; Dextroamphetamine; Dopamine; Homovanillic Acid;
Mesh terms: 3,4-Dihydroxyphenylacetic Acid/metabolism; Animals; Basal Ganglia/drug effects; Corpus Striatum/physiology; Dextroamphetamine/pharmacology; Dopamine/physiology; Hippocampus/physiology; Homovanillic Acid/metabolism; Ibotenic Acid/pharmacology; Male; Nucleus Accumbens/physiology; Rats; Rats, Inbred Strains; Synaptic Transmission/drug effects;