Selective increase of AMPA binding to the AMPA/quisqualate receptor in the hippocampus in response to acute stress.

Article date: 1991/9/13

PubMed ID: 1664274

Journal name: Brain research (ISSN: 0006-8993)


The binding properties of ligands specific for two subclasses of glutamate receptors were studied by quantitative autoradiography after one hour of acute immobilization/shock stress. [3H]N-(1-(2-thienyl)cyclohexyl)-3,4-piperidine (TCP) and [3H]alpha-amino-3-methylisoxazole-4-propionic acid (AMPA) were used to visualize the N-methyl-D-aspartate receptor and the AMPA/quisqualate receptor types, respectively. While no change was observed in the binding properties of the [3H]TCP, [3H]AMPA binding was significantly increased in several areas of the hippocampus of acutely stressed rats relative to naive controls.

Author List: Tocco G, Shors T J, Baudry M, Thompson R F

Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Ibotenic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; tenocyclidine; Phencyclidine;

Mesh terms: Animals; Autoradiography; Electroshock; Hippocampus/anatomy & histology; Ibotenic Acid/analogs & derivatives; Phencyclidine/analogs & derivatives; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate/drug effects; Receptors, Neurotransmitter/metabolism; Restraint, Physical; Stress, Psychological/metabolism; Synaptic Transmission/physiology; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

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