GABA/BZ-and NMDA-receptor interaction in digoxin-induced convulsions in rats.

Article date: 1991/7/1

PubMed ID: 1665475

Journal name: Indian journal of experimental biology (ISSN: 0019-5189)


Digoxin (7.5 micrograms icv) induced 'pop-corn' type of convulsions and 100% mortality. The GABA-ergic agents produced varying degree of protection against digoxin-induced neurotoxicity. Diazepam (4 mg/kg) offered significant protection whereas pentobarbital (5 mg/kg) and baclofen (5 mg/kg) markedly reduced per cent mortality, but ethanol (2 g/kg), progabide (50 mg/kg) and muscimol (0.5 mg/kg) as well as GABA (50 mg/kg) could not offer significant protection in doses used. GABA-ergic agonists; GABA, baclofen, diazepam and pentobarbital when administered along with MK-801 (0.5 mg/kg) a non-competitive NMDA antagonist, a potentiation of anticonvulsant action of MK-801 was observed. MK-801 showed potent anticonvulsant profile in dose range (0.25-1 mg/kg) studied. A synergistic influence of Mg2+ and K+ ions on NMDA receptor antagonism was also observed. A role of GABA-ergic facilitation and NMDA antagonism as a potential anticonvulsant approach in digoxin-induced convulsions in rats has been suggested.

Author List: Gautam S K, Kulkarni S K

Publication Types: Journal Article

Substances mentioned in the article: Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Salts; Muscimol; progabide; gamma-Aminobutyric Acid; Dizocilpine Maleate; Digoxin; Baclofen; Pentobarbital; Diazepam;

Mesh terms: Animals; Baclofen/pharmacology; Diazepam/pharmacology; Digoxin/antagonists & inhibitors; Dizocilpine Maleate/pharmacology; Female; Injections, Intraventricular; Male; Muscimol/pharmacology; Pentobarbital/pharmacology; Rats; Rats, Inbred Strains; Receptors, GABA-A/drug effects; Receptors, N-Methyl-D-Aspartate/drug effects; Salts/pharmacology; Seizures/chemically induced; gamma-Aminobutyric Acid/analogs & derivatives;

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